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Lady Mary Wortley Montagu survived smallpox herself and witnessed the practice of variolation (inoculation with actual smallpox material) while living in Constantinople. She had her own children inoculated and courageously introduced the technique to British high society in the early 1700s. Despite facing heavy skepticism from doctors, her efforts paved the way for Jenner's later work. Photo: Jonathan Richardson the younger, Wikimedia Commons, Public domain.
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